Diabetes Research Centre, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4PW, UK. hmp23@leicester.ac.uk. NIHR Leicester Biomedical Research Centre, Leicester, UK. hmp23@leicester.ac.uk. Department of Health Science, University of Leicester, Leicester, UK. hmp23@leicester.ac.uk. Diabetes Research Centre, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4PW, UK. NIHR Leicester Biomedical Research Centre, Leicester, UK. NIHR ARC East Midlands, Leicester, UK. Cardiovascular Sciences Unit, Leicester Glenfeild Hospital, Leicester, UK. School of Biomedical Sciences, Newcastle University, Newcastle, UK. Clinical Sciences Centre, Aintree University Hospitals NHS Foundation Trust, Liverpool, UK. Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.